Curcumin & Curcuminoids
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چکیده
Turmeric in Latin is Curcuma longa. Turmeric is the yellow spice that gives flavor to curried dishes. In the Far East, Turmeric is valued for more than just its culinary uses. The herb has been employed in the Ayurvedic healing tradition for centuries. The active ingredient in turmeric is the intense yellow pigment that is called curcumin. Curcumin is composed of three curcuminoids and is generally thought of as an antioxidant although it is also a powerful COX2 inhibitor without side effects.
منابع مشابه
Factors Affecting the Accumulation of Curcumin in Microrhizomes of Curcuma aromatica Salisb
Curcuminoids, and mainly curcumin, are potential therapeutic agents for the prevention of various diseases; however, little is known about the factors that influence their accumulation in Curcuma species. In this study, the effects of factors such as sucrose concentration, different ratios of 6-benzylaminopurine (6-BA) and α-naphthalene acetic acid (NAA), and light quality on the accumulation o...
متن کاملSpectral and Photophysical Behaviors of Curcumin and Curcuminoids
In order to obtain detailed information on ground and excited states of curcumin and curcuminoids, as well as to understand the photobiological characteristics of them, their spectral and photophysical behaviors are investigated in various conditions. Various curcuminoids were obtained and their structures were determined by spectroscopic methods. In n-hexane, the absorption and fluorescence sp...
متن کاملCurcuminoids form reactive glucuronides in vitro.
Curcumin is of current interest because of its putative anti-inflammatory, anticarcinogenic, and anti-Alzheimer's activity, but its pharmacokinetic and metabolic fate is poorly understood. The present in vitro study has therefore been conducted on the glucuronidation of curcumin and its major phase I metabolite, hexahydro-curcumin, as well as of various natural and artificial analogs. The predo...
متن کاملInhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease.
Curcuminoids (a mixture of curcumin, bisdemethoxycurcumin and demethoxycurcumin) share vital pharmacological properties possessed by turmeric, a well known curry spice, considered useful in Alzheimer's disease (AD). The aim of this study was to evaluate if curcuminoids possess acetylcholinesterase (AChE) inhibitory and memory enhancing activities. The in-vitro and ex-vivo models of AChE inhibit...
متن کاملDifferential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications
BACKGROUND Commercially available curcumin preparations contain a mixture of related polyphenols, collectively referred to as curcuminoids. These encompass the primary component curcumin along with its co-purified derivatives demethoxycurcumin and bisdemethoxycurcumin. Curcuminoids have numerous biological activities, including inhibition of cancer related cell proliferation and reduction of am...
متن کاملProduction of curcuminoids from tyrosine by a metabolically engineered Escherichia coli using caffeic acid as an intermediate.
Curcuminoids are phenylpropanoids with high pharmaceutical potential. Herein, we report an engineered artificial pathway in Escherichia coli to produce natural curcuminoids through caffeic acid. Arabidopsis thaliana 4-coumaroyl-CoA ligase and Curcuma longa diketide-CoA synthase (DCS) and curcumin synthase (CURS1) were used to produce curcuminoids and 70 mg/L of curcumin was obtained from feruli...
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